South Africa has committed to eliminating cervical cancer as a public health problem by 2030 in alignment with the World health Organization (WHO) Global Strategy.

This Strategic and Implementation Framework provides a unified national roadmap to accelerate progress, address persistent inequalities, and sustain gains across the full continuum of prevention, screening, treatment, survivorship and palliative care. This Framework is grounded in the 90–70–90 targets: vaccinating 90% of girls against HPV by age 15 years; screening 70% of women with a high-performance test by ages 25 and 55; and ensuring 90% of women diagnosed with precancer receive early treatment and 90% of those with invasive cancer receive appropriate and comprehensive treatment.

Over the past five years, the country has achieved major policy and programmatic milestones that position it strongly for elimination. These include sustained school-based HPV vaccination reaching over 500 000 girls annually, screening of over 800 000 women per year, a full national transition to HPV-DNA based screening, and expansion of oncology services amongst others. These advances form the foundation upon which this Framework builds.