This manual is intended to: Provide policy guidelines Set standards on immunisation practices Address practical issues that the vaccinator normally faces What is new in this manual? The manual includes changes made to policies relating to the EPI program. These are: The addition of inactivated polio vaccine (IPV) while maintaining the birth and 6 week doses of OPV The introduction of rotavirus vaccine at 6 and 14 weeks The introduction of pneumococcal conjugate vaccine at 6 weeks, 14 weeks and 9 months The introduction of human papillomavirus (HPV) vaccine at 9 years for Grade 4 girls The switchover from the pentavalent, DTaP-IPV//Hib vaccine (pentaxim) to the hexavalent, DTaP-IPV-HB-Hib vaccine (hexaxim) which contains the acellular form of pertussis, hepatitis B and inactivated polio vaccine in addition to the diphtheria, tetanus and pertussis combination. One additional module on new vaccines has been incorporated to include more information on the new vaccines.