The South African National Strategic Plan on HIV, TB and STIs 2017 - 2022 (NSP) serves as a roadmap for the next stage of our journey towards a future where these three diseases are no longer publichealth problems. This plan sets out the destinations - or goals - of our shared journey and establishes landmarks in the form of specific measurable objectives. The purpose of the NSP is to enable the many thousands of organisations and individuals who drive the response to HIV, TB and STIs to act as a concerted force, moving in the same direction.