he purpose of this guideline is to ensure that healthcare providers at all levels of care in South Africa are following the most up-to-date recommendations for post-exposure prophylaxis for HIV and HBV, following either occupational or non-occupational exposure to blood or bodily fluids. Application of these guidelines by health care workers will improve access and adherence to PEP. Additionally, recommendations for PEP for sexually transmitted infections (STls), tetanus, and the prevention of unwanted pregnancies are also provided. This guideline aligns with the South African Primary Healthcare Level Essential Medicines List (2019), the WHO PEP guidelines (2014) and the Southern African HIV Clinicians Society guidelines (2015), promoting simplification and adherence support to individuals receiving PEP.