The WHO defines HIV self testing (referred to self-screening in this document) as a voluntary process in which a person collects his or her own specimen (oral fluid or blood) and then performs a screening test and interprets the result, often in a private setting, either alone or with someone he or she trusts. It should be offered as an additional approach to existing HTS, and not replace it. The overall goal of HIV self-screening is to improve HIV testing among the historically HIV under-tested, test-averse and hard to reach groups, such as men, adolescent girls and young women (AGYW). It seeks to improve couple testing among pregnant women and lactating mothers and provides an option for regular repeat HIV testing in high risk populations. The overall goal of HIV self-screening is to improve HIV testing among the historically HIV under-tested, test-averse and hard to reach groups, such as men, adolescent girls and young women (AGYW). It seeks to improve couple testing among pregnant women and lactating mothers and provides an option for regular repeat HIV testing in high risk populations. The HIVSS guidelines should be read in conjunction with the National HIV Testing Services Policy (2016). This document provides guidance on the provision of HIVSS; linkage to services; quality assurance to ensure accurate results; and how to position HIVSS as an additional approach to HTS.