The clinical guideline on safe conception and infertility is responding to the National Health Insurance (NHI) principle of universal health access for all. It aims to promote, protect, and ensure the full and equal enjoyment of all human rights and fundamental freedoms by all, including persons with disabilities, and to promote respect for their inherent dignity. The guideline is also addressing the needs of lesbian, gay, bisexual transgendered and intersex, (LGBTQI) population in the context of their reproductive rights that has been lacking. Currently, the demand for services to help these communities to build a family is on the rise. This requires an adequate and rights-based response from the country and the health care providers as a whole. The guideline is intended to present an approach to prevention, management and psychosocial care of people seeking infertility treatment, and seeks to fill the clinical and policy gap in South Africa, as outlined in the 2019 Integrated Sexual and Reproductive Health Policy document. In South Africa, one in six couples experience some form of infertility . The estimates of prevalence are not very accurate because some cases are not reported.