Malaria is a potentially fatal disease that can be prevented in most instances by taking the appropriate precautions. These guidelines, produced by the national Department of Health, provide detailed options available for preventing malaria transmission. The primary objective of these guidelines is to provide healthcare practitioners with information on the most appropriate interventions for people entering malaria-affected areas. These guidelines include recommendations from the World Health Organization’s (WHO) guidelines for the prevention of malaria. The guidelines presented here include information on non-drug measures to prevent mosquito bites, determining whether chemoprophylaxis is indicated, selecting the most appropriate chemoprophylaxis to use, including the interactions between malaria chemoprophylaxis and other drug treatments, and the benefits and risks of alternative chemoprophylactic agents. An updated map of malaria risk in South Africa and detailed tables on antimalarial drug dosages have been included.