The Clinical Guidelines for Breast Cancer Control and Management is aimed at providing detailed information regarding the standards laid out in the Breast Cancer Prevention and Control Policy – its companion document. These standards include awareness, prevention, and treatment and care in the South African context. It provides clinicians with the step-by-step guidance from the initial contact with the patient to the discharge back into the community. The implementation of these clinical guidelines will reduce the breast cancer related mortalities. The clinical guidelines will also provide an opportunity to respond to the health system priorities related to cancers.It provides guidelines on the required minimum standard to establish Regional Breast Units (RBUs), including list of essential equipment, essential medicines, and personnel required. It further provides guidance on collaboration with civil society and private partners in fighting the battle against cancer.